Meet The Gregg Lab Team
Dr. Christopher Gregg, PhD.
I completed my PhD in Canada with Dr. Samuel Weiss (University of Calgary) in the field of neural stem cells. In 2004, I participated in the founding of a biotechnology company called Stem Cell Therapeutics, which is developing treatments for Stroke & Multiple Sclerosis. I subsequently trained as a postdoctoral fellow at Harvard with Dr. Catherine Dulac and began to use next generation sequencing technology to explore differences in gene expression from maternally versus paternally inherited chromosomes in the mouse brain. As an Assistant Professor in the Department of Neurobiology & Anatomy at the University of Utah, I am interested in discovering epigenetic and genetic mechanisms that shape complex behavior patterns and disease risks. My passions are ideas and discovery. I love working with and mentoring creative people!
Susan graduated with a degree in animal sciences with focus on animal behavior at UC Davis. She has over two years of experience in lab animal care.
Susan helps to manage the lab, mouse colony and behavior facility. She is developing and optimizing new and established methods to screen mouse models for behavioral phenotypes.
Paul Bonthuis, PhD.
Noncanonical genomic imprinting in the brain
Dr. Paul Bonthuis brings extensive experience in molecular biology, mouse genetics and animal behavior to the lab. He worked as a research technologist in the Department of Genome Sciences at the University of Washington for 4 years and then in the Bacterial Pathogens Research Group at the Seattle biomedical Research Institute. Dr. Bonthuis then carried out his PhD. studies with Dr. Emilie Rissman at the University of Virginia. His work focused on the roles of X-linked genes in regulating sexually dimorphic social behaviors.
In 2015, the Gregg lab identified novel noncanonical genomic imprinting effects in the brain that cause preferential silencing of either the maternally or paternally inherited allele for some genes. Paul is testing the hypothesis that noncanonical imprinting is a highly cell-type specific form of heritable epigenetic gene regulation through which mothers and fathers influence offspring brain function and behavior. His work involves novel CRISPR-Cas9 mediated genome engineering methods, imaging, deep behavioral screening, mouse genetics and bioinformatics. (See Bonthuis et al. Cell Reports 2015)
Wei-Chao Huang, PhD.
Wei-Chao completed a Master’s degree In Taiwan focused on the study of stem cells. He brings strong molecular and cell culture expertise to the lab. As a graduate student in the Gregg lab, Wei-Chao, along with Elliott Ferris, described novel allele-specific epigenetic effects that shape gene expression in an age and cell dependent manner (See Huang and Ferris et al. Neuron 2017).
As a postdoc, Wei-Chao is working to understand how these allelic effects shape phenotypes and disease risks. He is involved in a spin off startup company to translate his work into the clinic.
Graduate Student (joint with Aaron Quinlan’s lab in Human Genetics)
Models, Postdoctoral Fellow (2012-2017)
Dr. Coni Horndli completed her Master’s Thesis at the University of Zurich, Switzerland, in the Department of Zoology. She focused her studies on understanding the role of cadherins in the spinal cord. Coni then completed her PhD in Professor Chi-Bin Chien’s laboratory at the University of Utah School of Medicine and studied the role of Sonic Hedgehog signaling in the regulation of axon pathfinding in the retinal system of zebrafish.
As a postdoc in the Gregg lab, Coni developed novel behavioral paradigms and computational methods for a new field of behavior analysis called “computational ethology”. She successfully developed new ways to screen and analyze behavior using computational approaches that analyze hundreds of behavioral features in mouse models. Her methods have been adopted in the lab and by collaborators at other institutes. Coni is an expert in data analysis and presentation.
Tong (tina) Cheng
Tina worked as the Gregg lab manager and technician for several years. She optimized methods for histological studies of allele-specific gene expression at the cellular level, and developed various in vitro and molecular assays. Tina translated discoveries in the lab to a startup spin off company.
Undergraduate Student (2014-2016)
The Gregg Lab welcomes strong candidates to apply to the lab as graduate students, postdoctoral fellows or professional scientists.
Individuals with experience/interest in genomics, neuroscience, bioinformatics & programming, molecular biology, animal behavior or mouse genetics are especially encouraged to apply