Imprints on our Biology that Determine our Behavior Our recent study in Cell Reports is big step forward towards our vision of integrating naturalistic behavior, machine learning and genetics to understand the cellular and molecular basis of mammalian decisions and actions. This is important work, since our behavior, including our decisions and actions, are the … Read more
It is good to regularly reflect on your life plan, perspectives and progression. A logical time to do it is during the Christmas and New Years break. I like to write and store this in Evernote, so it easy to find. Here are some questions I recommend answering as you prepare for the year. Look … Read more
A postdoctoral fellow in my lab recently got an outstanding tenure-track faculty position with a great startup package and hard salary. This is so exciting! But at the same time, I hear of trainees overcome with fear because they feel the road to a tenure-track position is simply too hard and competitive. This is worrisome … Read more
The science website, STATnews , runs an annual competition called STAT madness to select the biggest and best science idea of the year. Go here to read about the STAT madness competition for 2019 and the contenders for this year’s crown. Our accelerated evolution paper (published in Cell Reports last year) has been selected as one of … Read more
A LEAN CANVAS-STYLE APPROACH TO DEVELOPING GREAT GRANTS AND PROJECTS Writing a great grant or designing a transformative new project is hard work and many issues need to be considered carefully. An idea for grant application/project will typically go through many, many iterations before something great emerges. During this process, many different ideas and … Read more
Getting Away With Murder Murder is a serious, but alarmingly prevalent phenomenon in academic science. Every minute, someone somewhere kills another person’s idea. After years of labor, a researcher puts together a paper detailing a question, data gathered and the interpretation of the results. Each paper is a partially correct story presenting an idea and … Read more
Creative science involves obsessive information gathering and thinking to generate a lot of ideas. Most ideas are partially or completely bad/wrong in their initial form. It takes years of sculpting to chisel out a great knowledge product. You do not want to spend years pursuing bad/wrong ideas, but in most cases it is not immediately … Read more
This post presents R code to retrieve SNPs in promoters for a list of genes. You provide your list of genes to the “gene” variable and then use biomaRt (mus_musculus) to get the transcriptional start sites (TSS) for each transcript for your list of genes.
2012 INNOVATOR OF THE YEAR AWARD The 2012 Gregg Lab Innovator of the Year is Sridhar Vukkadapu. Sridhar is completing his Master’s Degree in computer science and has worked in the lab for one year.
An Exon Splice Enhancer Primes IGF2:IGF2R Binding Site Structure and Function Evolution Christopher Williams,1* Hans-Jürgen Hoppe,2* Dellel Rezgui,2 Madeleine Strickland,1 Briony E. Forbes,3 Frank Grutzner,3 Susana Frago,2 Rosamund Z. Ellis,1 Pakorn Wattana-Amorn,1 Stuart N. Prince,2 Oliver J. Zaccheo,2 Catherine M. Nolan,4 Andrew J. Mungall,5 E. Yvonne Jones,6 Matthew P. Crump,1† A. Bassim Hassan2†
By: Dr. Paul Bonthuis PhD. Two simultaneous reports by Garrison et al. and Beets et al. in last week’s issue of Science discovered a C. elegans peptide neurotransmitter, and two cognate receptors, with genetic, structural, and functional similarity to the mammalian oxytocin/vasopressin (and non-mammalian vertebrate vasotocin) signaling systems.
Stephanie Watson at WebMD has written a nice article for a general audience that addresses some of the basic issues related to maternal health and the long-term health of children – “Blame Your Health on Mom? Not so fast“.
As much as I can, I will post helpful links for career planning for trainees. While there is a lot of vague crap written about transitioning into industry from academic science, there are a few gems.
Thank you to everyone sending congratulatory messages regarding the Eppendorf & Science Prize. A link to my essay is provided here: Parental Control Over the Brain
The faculty of 1000 (F1000) is a post-publication peer review process performed by leading scientists that ranks publications in a variety of scientific fields. Our paper has the number one spot in Neuroscience! Fantastic.
Life is full of stress. Jobs are lost, divorces ensue, accidents happen…even wars and terrorism are a part of life for some. There is no doubt that these things impact tremendously on children, but could chronic stress in one generation really influence future descendants for generations to come?
I have been searching for a good way to manage projects and ideas within the lab. I especially want to find a way to motivate creativity and productivity.
Why won’t my Perl script parse the CSV or tab-delimited table I just exported from Excel?
Genomic imprinting is one of the most provocative and exciting fields of research falling under the umbrella of “epigenetics”.Imprinting is thought to be a rare, but extraordinarily important mode of gene regulation in the genome and is the primary focus of my research.For this post, I am putting up an excerpt from Brady Weissbourd’s undergraduate thesis.